Both hormones modulate neurotransmitter synthesis and release, immunity and inflammation, endothelial and cognitive function, and neurogenesis and neuronal survival. Independent of age, serum levels of DHEA-S appear to be positively correlated with healthier psychological profiles - executive function, working memory, attention, concentration, enjoyment of leisure activities and overall stress-buffering effect [3].
Imbalance in the DHEA pool tends to be associated with distress and psychopathology, such as depression, anxiety, bipolar disorder, eating disorders, PTSD and perceived stress [9] [10] [11]. Moreover, lower DHEA levels go hand-in-hand with the degree in severity of depression [13]. And on the flip-side, too-high levels have been detected in patients with mania [14]. The fascinating thing about neurosteroids is that they work in a slightly different fashion.
There is considerable ambiguity regarding whether a DHEA receptor does, in fact, exist. Specifically, these neurosteroids modulate neuronal excitability by directly interacting with neurotransmitter systems, such as dopamine, serotonin, glutamate, and GABA amongst others [15].
Crudely, all of this means that DHEA-S helps keep that fire going — that the excitatory neurons are firing properly, but also that the fire is burning "just right" and is not out of control. For example, both molecules can stimulate dopamine release, a neurotransmitter well-known for being the "pleasure center" of the brain. However, the paths to raise dopamine are different. DHEA-S uses genomic, slow, long-lasting mechanisms to do so by upregulating tyrosine hydroxylase levels, the enzyme responsible for dopamine production.
DHEA, on the other hand, signals to increase dopamine levels in rapid, intense, short-lived bursts. While DHEA is available over the counter in health food stores, it is best used under medical supervision with the goal of restoring low levels to the physiological range. When treating a patient with low androgen symptoms and low DHEA-S levels, it is important to consider the route of hormone administration e.
When administered topically, DHEA restores skin elasticity, relieves symptoms of vaginal dryness and atrophy with vaginal application , and generally improves many low-androgen symptoms [16]. The caveat with topical DHEA administration is that it does not undergo first-pass metabolism through the liver no liver passage - no sulfation , so although a subsequent increase in salivary and blood spot DHEA is observed, DHEA-S levels remain unchanged. The levels of the hormone in saliva represent the "free" hormone fraction, available for tissue uptake.
If low androgen symptoms persist with topical DHEA treatment, switching to oral dosing may prove to be a more effective strategy. With oral DHEA administration we see a substantial spike in DHEA-S levels in all commonly tested body fluids saliva , blood spot , serum, or urine undergoes first-pass metabolism and gets sulfated , and a marked improvement in symptoms as well. How you take DHEA definitely impacts how much gets into the brain and how fast.
Some patients are particularly sensitive even to small amounts 5 mg of DHEA administered this way - with agitation being a common side effect. In this case, taking DHEA orally could have a more gentle uplifting sensation of wellbeing. Since the discovery of neurosteroids in the early 80s, significant efforts have been poured into studying the role they play in brain-related disorders.
Use of this supplement might increase levels of androgen and have a steroid effect. DHEA also might increase the risk of hormone-sensitive cancers, including prostate, breast and ovarian cancers. If you have any form of cancer or are at risk of cancer, don't use DHEA. Consider avoiding use of DHEA if you have high cholesterol or a condition that affects the supply of blood to the heart ischemic heart disease. Use of DHEA also might worsen psychiatric disorders and increase the risk of mania in people who have mood disorders.
DHEA also might cause oily skin, acne and unwanted, male-pattern hair growth in women hirsutism. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health. Error Email field is required. Error Include a valid email address.
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